Benzimidazoles like Fenbendazole, Mebendazole, and Albendazole seem to be safe medications based on toxicological research.
However, there is no such thing as a medicine without any negative effects. Fenbendazole does not seem to have any severe side effects, according to scientific evidence. Despite this, there have been reports of possible toxicity:
- When taking high amounts of fenbendazole without pauses, up to 5% of persons may have stomach pain or diarrhea.
- Fenbendazole may build and create unanticipated adverse effects in those who have severe liver or renal failure because their drug excretion rates are decreased. In this circumstance, the doses should be split as needed. The program was created to preserve the liver in peak condition, therefore a three-day on, four-day off schedule is recommended.
- Because fenbendazole is mostly processed in the liver, it might induce an asymptomatic rise in liver enzymes when taken in high amounts for a lengthy period without interruptions. With the aid of a two-week break, this may be reversed.
The weekly pattern of 3 days on, 4 days off was proposed since the treatment was meant to maintain the liver in peak condition.
However, an increasing number of patients are taking fenbendazole in 5-day-on, 2-day-off cycles.
To maintain optimum liver function, we recommend taking 250 mg Milk Thistle capsules or 150 mg Silymarin capsules daily as a supporting supplement.
Supplements to take with fenbendazole
- Vitamin E 800 U/I, taken once a day after a meal in a tablet or other form.*
Vitamin E and Fenbendazole synergistic combination on cancer was proven back in 2011.
- 600 mg Bio-Available Curcumin After breakfast and lunch, take one capsule twice a day.
- 25 mg CBD oil Every day before bed, take 1-2 drops (total 25 mg) under the tongue.
- Fenbendazole and other vitamins:
Vitamin B1 and other B group vitamins may work together to boost fenbendazole’s anticancer properties. A cancer therapy program using fenbendazole or other benzimidazole medicines might benefit from extra B1, B6, and B9 intake, as well as Vitamin D. - D (vitamin D). Please get your Vitamin D levels checked by your doctor regularly. Vitamin D3 is preferable to vitamin D2. Supplementing with Vitamin D has been shown to boost immunity and improve the prognosis of cancer patients.**
Fenbendazole seems to function best when combined with supplementary vitamin supplements. Other vitamins that aren’t mentioned are also acceptable as a supplement to cancer therapy.
*- “Fenbendazole has an Unexpected Antitumorigenic Effect When Used in Combination with Supplementary Vitamins.” Most notably, we discovered that fenbendazole in conjunction with vitamins supplied greatly slowed tumor development.”
**- a meta-analysis of the effects of vitamin D supplementation on cancer incidence and death. Cancer incidence was unaffected by vitamin D administration, but death was dramatically decreased.”
Fenbendazole metabolism
Following absorption, fenbendazole undergoes two distinct transformations in the body: hydroxylation and oxidation.
The first step is carried out by the liver enzymes CYP2J2 and CYP2C19. Fenbendazole is hydroxylated to produce hydroxyfenbendazole, a novel metabolite.
The oxidation of the sulfide group is the second step. The enzymes CYP3A and flavin-containing monooxygenase catalyze this in the liver. As a consequence, a new molecule called oxfendazole is formed (which also displays anticancer and anthelmintic properties).
These data show that fenbendazole for sale is both a drug and a prodrug since it leads to another active drug that is created metabolically.
Because of its limited bioavailability, fenbendazole is not completely converted to its metabolites. Fenben is only absorbed in trace amounts via our gastrointestinal system. Fenbendazole, along with hydroxyfenbendazole and oxfendazole, is eventually eliminated in the feces.
Remember this! CYP2C19, an enzyme involved in the metabolism of fenbendazole, is also involved in the metabolism of tamoxifen, ebastine, amiodarone, astemizole, mesoridazine, apixaban, thioridazine, and cyclosporine.
If a cancer patient decides to take one or more of these treatments together with higher doses of fenbendazole, she or he should speak with her or his doctor to learn more about the interactions between fenbendazole and these drugs, as well as potential extra side effects and increased toxicity.
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